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. Author manuscript; available in PMC: 2013 Apr 27.
Published in final edited form as: Cell. 2012 Apr 27;149(3):565–577. doi: 10.1016/j.cell.2012.01.059

Figure 2. Correction of the Lmna−/− skeletal defects in the Lmna−/−Sun1−/− double knock out mouse.

Figure 2

(A) Micro-CT scans of the indicated mice. Lmna−/− mice display a lordokyphosis (curvature of the spine) phenotype corrected in Lmna−/−Sun1−/− mice.

(B) Three-dimensional micro-CT images of the femoral trabeculae from 40-day-old mice (left panels). Thinner trabecular formation was observed in the Lmna−/− mouse compared to the other genotypes. Right panels quantify bone density+/−SD (upper) and the number of trabeculaes/mm+/−SD (lower). P values are shown. (see also Figure S1)