Phosphorylated levels of PKCζ/ι and PKMζ are elevated 28 days post-C2 hemisection. Phosphorylated aPKC expression was measured by immunoblots in ventral C3–5 homogenates either ipsi- or contralateral to injury from sham (white bar) and C2 hemisected (black bar) rats. (A) 28 days post-injury, phosphorylated PKCζ/ι expression is significantly increased on the ipsilateral versus contralateral sides (p=0.012), although neither side was significantly different from sham rats. (B) 28 days post-injury, phosphorylated PKMζ expression is significantly higher ipsilateral, but not contralateral to injury (C2HS v. sham, p=0.022; ipsi v. contra, p=0.003).