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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Biol Psychol. 2012 Mar 10;90(2):134–142. doi: 10.1016/j.biopsycho.2012.03.001

Table 3.

Anatomical Locations of Increased Activation in Response to Threatening versus Happy and Neutral Face Pair Trials (p<.005)

PTSD versus TC group
x y z k t Brodmann Area Anatomical location
−44 −65 18 12 3.71 39 Middle temporal gyrus
16 −26 16 6 3.61 Thalamus
4 51 1 10 3.37 10 Medial frontal gyrus
−51 −31 2 9 3.21 21 Middle temporal gyrus
−40 43 2 5 3.03 46 dlPFC
TC versus PTSD group
x y z k t Brodmann Area Anatomical location
−28 −78 −6 5 3.48 18 Middle occipital gyrus
−16 −54 −1 12 3.44 19 Lingual gyrus
12 −62 10 7 2.97 30 Posterior cingulate
Correlation of threat bias scores with activation to threatening versus neutral and happy face pair trials
PTSD
Positive correlation
x y z k t Brodmann Area Anatomical location
−8 −89 4 5 4 17 Lingual gyrus
Negative correlation
x y z k t Brodmann Area Anatomical location
20 −56 47 10 3.67 7 Precuneus
20 6 48 10 3.28 6 Medial frontal gyrus
−16 19 −4 15 3.27 Caudate
−24 24 6 2.75 Claustrum
32 −17 41 47 3.22 4 Precentral gyrus
36 −10 37 3.09 6 Precentral gyrus
32 −45 32 2.90 40 Parietal lobe
−20 −38 17 8 3.21 Caudate
−28 30 −12 10 3.20 47 vlPFC
−36 −10 34 6 3.06 6 Precentral gyrus
−44 −27 −2 5 3.06 22 Insula
51 −10 37 11 3.05 4 Precentral gyrus
−28 −54 10 6 3.05 30 Parahippocampal gyrus
−20 −46 10 3.04 30 Precentral gyrus
24 −36 57 5 2.99 40 Parietal lobe
12 −14 27 7 2.91 Caudate
−8 43 2 7 2.87 32 Anterior cingulate cortex
TC
Positive Correlation
x y z k t Brodmann Area Anatomic Location
−20 −8 −13 7 3.76 Parahippocampal gyrus
−51 −24 −6 14 3.54 21 Middle temporal gyrus
−51 −12 −9 3.50 22 Superior temporal gyrus
−59 −43 2 6 3.41 21 Middle temporal gyrus
−59 −50 10 3.21 22 Superior temporal gyrus
Correlation of TEI score with activation to threatening versus neutral and happy face pair trials
Positive Correlation
x y z k t Brodmann Area Anatomic Location
20 −66 −7 91 6.44 19 Lingual gyrus
32 −70 −10 6.20 18 Lingual gyrus
12 −74 0 4.18 18 Lingual gyrus
−28 −67 −10 150 5.54 19 Fusiform gyrus
4 −65 14 5.33 31 Posterior cingulate
−12 −69 18 4.56 18 Cuneus
−16 −47 −4 26 5.40 Cerebellum
−24 −77 19 47 5.17 18 Cuneus
−28 −89 12 3.63 18 Middle occipital gyrus
20 −88 19 58 4.51 18 Cuneus
28 −65 25 3.53 31 Precuneus
12 −84 23 3.19 18 Cuneus
20 −47 −1 18 3.79 19 Parahippocampal gyrus
20 −58 7 3.35 30 Posterior cingulate
Negative Correlation
x y z k t Brodmann Area Anatomic Location
−48 −20 −16 5 3.04 20 Inferior temporal gyrus

dlPFC = dorsolateral prefrontal cortex

vlPFC = ventrolateral prefrontal cortex