Table 6. Hit expansion for ligand 8.
| ID | IC50 [M] (SD)* | Hill slope (SD)* | Ligand efficiency [kcal/mol per non-hydrogen atom] |
| 8 | 2.5·10−6 (4·10−7) | 1.3 (0.1) | 0.35 |
| 21 | 2.7·10−5 (9·10−6) | 1.1 (0.3) | 0.28 |
| 22 | 1.8·10−4 (4·10−5) | 0.8 (0.1) | 0.26 |
| 23 | 3.2·10−4 (8·10−5) | 0.7 (0.1) | 0.23 |
| 24 | n.i.a | - | - |
| 25 | n.i. | - | - |
| 26 | n.i. | - | - |
| 27 | n.i. | - | - |
| 28 | n.i. | - | - |
| 29 | n.i. | - | - |
| 30 | n.i. | - | - |
For chemical structures see Figure 16.
*
average values of three independent measurements, standard deviation in brackets.
a
no inhibition at solubility limit measured.