Fig. 5.

Insulin sensitivity and plasma substrates during the hyperinsulinemic euglycemic (insulin) clamp. A: glucose infusion rate (GIR) during the insulin clamp. The GIR is equivalent to glucose disposal rate in response to insulin stimulation. The GIR is presented as a time course starting 20 min prior to administration of 2-[¹⁴C]DG and [¹²⁵I]BMIPP (−20-min time point) until 30 min following 2-[¹⁴C]DG and [¹²⁵I]BMIPP infusion (30-min time point). B: arterial plasma glucose concentration following 2-[¹⁴C]DG and [¹²⁵I]BMIPP injection. C: arterial plasma nonesterified fatty acids (NEFA) in mice following 2-[¹⁴C]DG and [¹²⁵I]BMIPP injection. Data are means ± SE for n = 8–12 mice/group.