Table 2.
Baseline |
7 Days |
23 Days |
|||||||
---|---|---|---|---|---|---|---|---|---|
SHAM | MI + PBS | MI + MSC | SHAM | MI + PBS | MI + MSC | SHAM | MI + PBS | MI + MSC | |
HR, beats/min | 694 ± 4 | 673 ± 7 | 676 ± 10 | 706 ± 13 | 685 ± 22 | 697 ± 6 | 700 ± 10 | 673 ± 18 | 692 ± 9 |
FS | 0.500 ± 0.005 | 0.495 ± 0.002 | 0.503 ± 0.004 | 0.488 ± 0.005 | 0.376 ± 0.008* | 0.466 ± 0.005† | 0.484 ± 0.004 | 0.360 ± 0.009* | 0.455 ± 0.007*† |
EF | 0.864 ± 0.004 | 0.866 ± 0.002 | 0.871 ± 0.003 | 0.858 ± 0.004 | 0.743 ± 0.01* | 0.840 ± 0.004† | 0.853 ± 0.004 | 0.723 ± 0.01* | 0.828 ± 0.008† |
IVSd, cm | 0.067 ± 0.001 | 0.066 ± 0.001 | 0.063 ± 0.001*† | 0.071 ± 0.002 | 0.068 ± 0.002 | 0.068 ± 0.001 | 0.072 ± 0.002 | 0.073 ± 0.002 | 0.069 ± 0.002 |
LVIDd, cm | 0.287 ± 0.004 | 0.289 ± 0.002 | 0.293 ± 0.004 | 0.300 ± 0.005 | 0.340 ± 0.01* | 0.301 ± 0.007† | 0.290 ± 0.006 | 0.354 ± 0.009* | 0.310 ± 0.008† |
LVPWd, cm | 0.052 ± 0.001 | 0.054 ± 0.001 | 0.054 ± 0.001 | 0.060 ± 0.002 | 0.066 ± 0.002 | 0.064 ± 0.002 | 0.060 ± 0.002 | 0.062 ± 0.002 | 0.064 ± 0.002 |
IVSs, cm | 0.119 ± 0.002 | 0.116 ± 0.002 | 0.110 ± 0.002* | 0.120 ± 0.001 | 0.106 ± 0.003* | 0.115 ± 0.003 | 0.120 ± 0.002 | 0.114 ± 0.002 | 0.117 ± 0.004 |
LVIDs, cm | 0.145 ± 0.003 | 0.144 ± 0.001 | 0.146 ± 0.002 | 0.154 ± 0.003 | 0.213 ± 0.008* | 0.16 ± 0.004† | 0.150 ± 0.003 | 0.227 ± 0.008* | 0.169 ± 0.006† |
LVPWs, cm | 0.084 ± 0.001 | 0.081 ± 0.001 | 0.085 ± 0.002 | 0.085 ± 0.001 | 0.095 ± 0.003* | 0.095 ± 0.002* | 0.088 ± 0.002 | 0.090 ± 0.003 | 0.091 ± 0.002 |
Data are means ± SE for n = 15–19 mice/group. HR, heart rate; FS, fractional shortening; EF, ejection fraction; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricle end-diastolic dimension; LVPWd, left ventricle posterior wall thickness in diastole; IVSs, interventricular septal thickness in systole; LVIDs, left ventricle end-systolic dimension; LVPWs, left ventricle posterior wall thickness in systole.
P < 0.05 vs. SHAM at specified time point;
P < 0.05 vs. MI + PBS at specified time point.