Table 1.
Demographic and biophysical data for teenage and adult cohorts assessed for placental system A activity
| Category | Growing | Nongrowing | Adults |
|---|---|---|---|
| n | 6 | 9 | 19 |
| Age, yr | 17.4*** | 17.3*** | 29.0 |
| (15.9–18.6) | (16.1–18.8) | (20.0–43.0) | |
| Gynecological age, yr | 5.1 | 5.4 | |
| (2.9–6.3) | (3.1–7.5) | ||
| Primiparous, no. (%) | 6 (100.0)** | 9 (100.0)** | 13 (68.4) |
| Smokers, no. (%) | 4 (66.7)†††*** | 2 (22.2) | 3 (15.8) |
| BMI at booking, kg/m2 | 22.3 | 21.7 | 23.4 |
| (19.8–36.9) | (18.2–35.2) | (15.9–34.7) | |
| Underweight, no. (%) | 0 (0.0)†††*** | 3 (33.3)*** | 3 (15.8) |
| Normal, no. (%) | 4 (66.7) | 4 (44.4) | 11 (57.9) |
| Overweight, no. (%) | 1 (16.7) | 1 (11.1)* | 4 (21.0) |
| Obese, no. (%) | 1 (16.7)*** | 1 (11.1)* | 1 (5.3) |
| Knee height change, mm/90 days | 3.7††† | −0.02 | |
| (2.6–6.1) | (−1.2–1.0) | ||
| SGA <10th centile, no. (%) | 1 (16.7)** | 1 (11.1)** | 6 (31.5) |
| AGA 10th–90th centile, no. (%) | 5 (83.3)* | 8 (88.9)** | 12 (63.2) |
| LGA >90th centile, no. (%) | 0 (0.0)* | 0 (0.0)* | 1 (5.3) |
Values are median (and range) unless otherwise stated. Of the 33 teenagers from whom placentas were collected, maternal growth data were collected from 15 teenagers, subdivided into 6 growing and 9 nongrowing. Gynecological age defined as no. of years since menarche. Parous teenagers and adults had only one previous birth. BMI, body mass index; IBC, individual birthweight centile; SGA, small-for-gestational-age; AGA, appropriate-for-gestational-age; LGA, large-for-gestational-age.
*
P < 0.05,
**
P < 0.01,
***
P < 0.0001 teenagers vs. adults;
†††
P < 0.0001 growing vs. nongrowing teenagers.