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. 2011 Oct 12;302(2):F251–F263. doi: 10.1152/ajprenal.00378.2011

Fig. 2.

Fig. 2.

Effects of BRL37344 and L-755,507 on the spontaneous phasic and tonic contractions of guinea pig DSM isolated strips. A–B: original recordings of DSM spontaneous phasic contractions illustrating BRL37344 inhibitory effect (1 nM-100 μM) in the absence (A) or presence (B) of SR59230A (10 μM). C–G: concentration-response curves for BRL37344 (1 nM-100 μM) inhibitory effects on the spontaneous phasic contraction amplitude (C), muscle force integral (D), phasic contraction frequency (E), phasic contraction duration (F), and muscle tone (G) in the presence or absence of SR59230A (10 μM). Concentration-response curves for L-755,507 (1 nM-100 μM) showed no inhibitory effect on the spontaneous phasic and tonic contractions of DSM isolated strips (C–G). Spontaneous contractions were taken to be 100% (n = 7, N = 7 for BRL37344; n = 12, N = 6 for L-755,507; and n = 8, N = 4 for SR59230A + BRL37344; *P < 0.05 for the SR59230A effect). Tetrodotoxin (TTX; 1 μM) was present throughout the experiments.