Table 2. Genetic risk score and cardiovascular outcome association results.
Association of genetic risk score (using all 29 SNPs at 28 loci, parameterised using the average of SBP and DBP effects [=(SBP effect + DBP effect)/2] from the discovery analysis), tested in results from other GWAS consortia.
| Phenotype | Source | Effect | SE | P-value | # SNPs | Contrast top vs. bottom | N case/control or total | |||
|---|---|---|---|---|---|---|---|---|---|---|
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| (per SD of genetic risk score) | quintiles | deciles | ||||||||
| Blood pressure phenotypes | ||||||||||
| SBP [mmHg] | WGHS | 1.645 | 0.098 | (a) | 6.5*10−63 | 29 | 4.61 | 5.77 | (a) | 23,294 |
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| DBP [mmHg] | WGHS | 1.057 | 0.067 | (a) | 8.4*10−57 | 29 | 2.96 | 3.71 | (a) | 23,294 |
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| Prevalent hypertension | WGHS | 0.211 | 0.018 | (b) | 3.1*10−33 | 29 | 1.80 | 2.09 | (b) | 5,018/18,276 |
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| Prevalent hypertension | BRIGHT | 0.287 | 0.031 | (b) | 7.7*10−21 | 29 | 2.23 | 2.74 | (b) | 2,406/1,990 |
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Dichotomous endpoints
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| Incident heart failure | CHARGE-HF | 0.035 | 0.021 | (c) | 0.10 | 29 | 1.10 | 1.13 | (c) | 2,526/18,400 |
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| Incident stroke | NEURO-CHARGE | 0.103 | 0.028 | (c) | 0.0002 | 28 | 1.34 | 1.44 | (c) | 1,544/18,058 |
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| Prevalent stroke | UK-US Stroke Collaborative Group(SCG) | 0.075 | 0.037 | (b) | 0.05 | 29 | 1.23 | 1.30 | (b) | 1,473/1,482 |
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| Stroke (combined, incident and prevalent) | CHARGE & SCG | NA | NA | NA | 3.3*10−5 | NA | NA | NA | NA | 3,017/19,540 |
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| Prevalent CAD | CARDIoGRAM | 0.092 | 0.010 | (b) | 1.6*10−19 | 28 | 1.29 | 1.38 | (b) | 22,233/64,726 |
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| Prevalent CAD | C4D ProCARDIS | 0.132 | 0.022 | (b) | 2.2*10−9 | 29 | 1.45 | 1.59 | (b) | 5,720/4,381 |
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| Prevalent CAD | C4D HPS | 0.083 | 0.027 | (b) | 0.002 | 29 | 1.26 | 1.34 | (b) | 2,704/2,804 |
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| Prevalent CAD (combined) | CARDIoGRAM & C4D | 0.100 | 0.009 | (b) | 8.1*10−29 | 29 | 1.32 | 1.42 | (b) | 30,657/71,911 |
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| Prevalent chronic kidney disease | CKDGen | 0.014 | 0.015 | (b) | 0.35 | 29 | 1.04 | 1.05 | (b) | 5,807/61,286 |
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| Prevalent microalbuminuria | CKDGen | 0.008 | 0.019 | (b) | 0.68 | 29 | 1.02 | 1.03 | (b) | 3,698/27,882 |
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Continuous measures oftarget organ damage
| ||||||||||
| Left ventricular mass [g] | EchoGen | 0.822 | 0.317 | (a) | 0.01 | 29 | 2.30 | 2.89 | (a) | 12,612 |
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| Left ventricular wall thickness[cm] | EchoGen | 0.009 | 0.002 | (a) | 6.0*10−6 | 29 | 0.03 | 0.03 | (a) | 12,612 |
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| Serum creatinine | KidneyGen | −0.001 | 0.001 | (d) | 0.24 | 29 | 1.00 | 1.00 | (d) | 23,812 |
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| eGFR (4 parameter MDRD equation) | CKDGen | −0.0001 | 0.0009 | (d) | 0.93 | 29 | 1.00 | 1.00 | (d) | 67,093 |
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| Urinary albumin/creatinine ratio | CKDGen | 0.005 | 0.007 | (d) | 0.43 | 29 | 1.01 | 1.02 | (d) | 31,580 |
(a)
Units are the unit of phenotypic measurement, either per SD of genetic risk score, or as a difference between top/bottom quintiles or deciles.
(b)
Units are ln(odds) per SD of genetic risk score, or odds ratio between top/bottom quintiles or deciles.
(c)
Units are ln(hazard) per SD of genetic risk score, or hazard ratio between top/bottom quintiles or deciles.
(d)
Units are ln(phenotype) per SD of genetic risk score, or phenotypic ratio between top/bottom quintiles or deciles.