Table 1.
Sequence alignment of the EGS-targeted regions in the E. coli, P. falciparum, P. yoelli, and P. berghei gyrase A genes and the H. sapiens TOP2A (topo II) gene
Organism | Target DNA sequence |
E. coli | CGGTCAGGGTAACTTCGGT330 |
P. falciparum | AGGTTATGGTAATTTTGGT825 |
P. yoelli | TGGATATGGTAATTTTGGG870 |
P. berghei | CGGATATGGTAATTTTGGA786 |
H. sapiens | TGATTATTATAATTTTGAG6457 |
Numbers at right are the positions in the sequence alignment of the gene of the last 3′ nucleotide in this particular segment. Bold fonts are the complements of the nucleotides in the EGSs that were made in this study.