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. 2012 Apr 2;109(16):6078–6083. doi: 10.1073/pnas.1119073109

Fig. 2.

Fig. 2.

Solution structures of KIX in complex with FOXO3a CR2C-CR3. CR2C-CR3 interacts with KIX in two distinct conformations. Lowest energy solution structure of KIX and CR2C-CR3 in the 2b3l conformation with CR2C bound to the c-Myb site and CR3 bound to the MLL site (A) and 2l3b with CR2C bound to the MLL site and CR3 bound to the c-Myb site (B). The backbones of KIX, CR2C, CR3, and the linker are shown in green, red, yellow, and cyan, respectively. Each structural component of KIX and the termini of KIX and CR2C-CR3 are labeled. CR2C in the c-Myb site (C), CR3 in the c-Myb site (D), CR2C in the MLL site (E), and CR3 in the MLL site (F). The backbones of KIX, CR2C, and CR3 are colored as above, and the surface of KIX is shown in gray. The side chains of CR2C and CR3 that interact with KIX are shown in orange and magenta, respectively, and the side chains of KIX that interact with CR2C or CR3 are shown in blue.