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. 2012 Apr 6;109(16):6118-6123. doi: 10.1073/pnas.1200206109

Fig. 3.

Fig. 3.

Capsid shell proteins. (A) VP1A of the transcribing CPV model (yellow) superimposed on VP1A of nontranscribing CPV (blue). The direction of the apical domain tilt is indicated by an arrow. (B) A slab view of the turret of transcribing CPV (yellow) superimposed on nontranscribing CPV (blue). The structure in the red box is a copy of the VP1A of transcribing CPV (yellow) and a copy of the VP1A of nontranscribing CPV (blue), in the same orientation as that in A, indicating that the tilt of the VP1A apical domain gives rise to an enlarged capsid chamber. (C) Left: two copies of VP1A (red) and one of VP1B (blue) are superimposed on the density map of transcribing CPV. A peripentonal RNA channel and a rod-like density are indicated by an arrow. Right: two copies of VP1A (red) and a copy of VP1B (blue) are superimposed on the density map of nontranscribing CPV. These proteins have the same orientation as those on the left for comparison. The peripentonal channel on the left (transcribing) is wider than that on the right (nontranscribing). The small protrusion in the channel on the right is the side chain of VP1 Arg 653. (D) Location (arrow) of one of the peripentonal channels in the capsid shell formed by VP1A (red) and B (green). (E) The turret of transcribing CPV showing that a nodule-like structure blocks the pentameric channel at the fivefold axis.