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. 2012 Mar 26;109(16):E926–E933. doi: 10.1073/pnas.1106300109

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Fig. 5. — TCTP is involved in regulation of subcellular distribution and DNA-binding activity of Ku70 and Ku80 after γ irradiation. (A) Confluent U2OS cells transfected with Scr or TCTP siRNA were exposed to no, 50-, or 370-cGy radiation. Expression of TCTP, Ku70, and Ku80 in nuclei and cytoplasm fractions 30 min after irradiation was examined by Western blotting. Reaction of goat anti-rabbit IgG (sc-2030; Santa Cruz Biotechnology) with a protein of ∼30 kDa was used to verify equal loading of samples (loading control). (B) Ku70 (Right) and Ku80 (Left) DNA-binding activity in irradiated U2OS confluent cells expressing Scr or TCTP siRNA at 30 min after irradiation.