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The role of TCTP in DNA damage sensing and repair. TCTP is up-regulated by ionizing radiation, interacts with elements of DNA damage sensing and repair, and modulates radiation-induced cell-cycle checkpoints. HR, homologous recombination; HSPs, heat shock proteins; IR, ionizing radiation; MRN, MRE11–RAD50–NBS1; NHEJ, nonhomologous end joining; P, phosphorylation.
