Table 3.
RR of Second Cancer in 1,015 1-Year Survivors of Bilateral Rb
| Factor | All Second Cancers |
Bone Cancer |
Soft Tissue Sarcoma* |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Cancers | Crude Analysis |
Adjusted Analysis |
No. of Cancers | Crude Analysis |
Adjusted Analysis |
No. of Cancers | Crude Analysis |
Adjusted Analysis |
|||||||||||||
| RR | 95% CI | PLRT | RR | 95% CI | PLRT | RR | 95% CI | PLRT | RR | 95% CI | PLRT | RR | 95% CI | PLRT | RR | 95% CI | PLRT | ||||
| Family history of Rb | .08 | .05 | .99 | .79 | .89 | .97 | |||||||||||||||
| No/unknown | 187 | 1.0 (Ref) | 1.0 (Ref) | 62 | 1.0 (Ref) | 1.0 (Ref) | 50 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| Yes | 52 | 1.33 | 0.97 to 1.79 | 1.37 | 1.00 to 1.86 | 13 | 1.00 | 0.53 to 1.76 | 0.92 | 0.48 to 1.64 | 10 | 0.96 | 0.46 to 1.80 | 0.99 | 0.47 to 1.87 | ||||||
| Sex | .05 | .05 | .72 | .73 | .35 | .30 | |||||||||||||||
| Male | 114 | 1.0 (Ref) | 1.0 (Ref) | 42 | 1.0 (Ref) | 1.0 (Ref) | 36 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| Female | 125 | 1.29 | 1.00 to 1.66 | 1.29 | 1.00 to 1.66 | 33 | 0.92 | 0.58 to 1.45 | 0.92 | 0.58 to 1.46 | 24 | 0.78 | 0.46 to 1.30 | 0.76 | 0.45 to 1.27 | ||||||
| Age at Rb diagnosis, months | .01 | .005 | .48 | .34 | .01 | .008 | |||||||||||||||
| < 12 | 153 | 1.0 (Ref) | 1.0 (Ref) | 47 | 1.0 (Ref) | 1.0 (Ref) | 36 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| 12-23 | 65 | 0.84 | 0.62 to 1.11 | 0.81 | 0.60 to 1.08 | 20 | 0.84 | 0.49 to 1.39 | 0.89 | 0.51 to 1.49 | 22 | 1.20 | 0.70 to 2.03 | 1.14 | 0.66 to 1.93 | ||||||
| 24+ | 21 | 0.53 | 0.33 to 0.82 | 0.50 | 0.31 to 0.78 | 8 | 0.66 | 0.29 to 1.32 | 0.71 | 0.31 to 1.43 | 2 | 0.21 | 0.04 to 0.70 | 0.19 | 0.03 to 0.64 | ||||||
| Calendar year of Rb diagnosis | .02 | .61 | .46 | .76 | .21 | .69 | |||||||||||||||
| < 1970 | 182 | 1.41 | 1.06 to 1.92 | 1.09 | 0.79 to 1.52 | 49 | 0.83 | 0.52 to 1.36 | 0.93 | 0.57 to 1.55 | 46 | 1.46 | 0.82 to 2.75 | 0.87 | 0.45 to 1.75 | ||||||
| 1970+ | 57 | 1.0 (Ref) | 1.0 (Ref) | 26 | 1.0 (Ref) | 1.0 (Ref) | 14 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| Radiotherapy for Rb | < .001 | .001 | < .001 | .006 | .004 | .006 | |||||||||||||||
| No | 12 | 1.0 (Ref) | 1.0 (Ref) | 1 | 1.0 (Ref) | 1.0 (Ref) | 1 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| Yes | 227 | 2.37 | 1.39 to 4.47 | 2.37 | 1.37 to 4.52 | 74 | 9.26 | 2.06 to 163.3 | 7.05 | 1.55 to 124.8 | 59 | 7.38 | 1.63 to 130.4 | 7.16 | 1.55 to 127.1 | ||||||
| Chemotherapy for Rb | .06 | .18 | .02 | .03 | .15 | .29 | |||||||||||||||
| No | 127 | 1.0 (Ref) | 1.0 (Ref) | 34 | 1.0 (Ref) | 1.0 (Ref) | 30 | 1.0 (Ref) | 1.0 (Ref) | ||||||||||||
| Yes | 112 | 1.28 | 0.99 to 1.65 | 1.20 | 0.92 to 1.56 | 41 | 1.75 | 1.11 to 2.78 | 1.71 | 1.07 to 2.76 | 30 | 1.45 | 0.87 to 2.42 | 1.32 | 0.78 to 2.23 | ||||||
| Attained age, years | < .001 | < .001 | < .001 | < .001 | < .001 | < .001 | |||||||||||||||
| < 10 | 49 | 1.0 (Ref) | 1.0 (Ref) | 23 | 1.0 (Ref) | 1.0 (Ref) | 10 | 1.0 | (Ref) | 1.0 | (Ref) | ||||||||||
| 10-19 | 80 | 1.90 | 1.34 to 2.73 | 1.98 | 1.39 to 2.85 | 41 | 2.07 | 1.26 to 3.51 | 2.12 | 1.28 to 3.59 | 19 | 2.21 | 1.05 to 4.95 | 2.30 | 1.09 to 5.15 | ||||||
| 20-29 | 34 | 1.06 | 0.68 to 1.64 | 1.12 | 0.71 to 1.73 | 7 | 0.47 | 0.18 to 1.03 | 0.48 | 0.19 to 1.07 | 6 | 0.92 | 0.31 to 2.47 | 0.98 | 0.33 to 2.66 | ||||||
| 30-39 | 46 | 2.47 | 1.65 to 3.69 | 2.61 | 1.71 to 3.97 | 3 | 0.34 | 0.08 to 0.98 | 0.36 | 0.08 to 1.05 | 19 | 4.99 | 2.37 to 11.18 | 5.52 | 2.51 to 12.93 | ||||||
| 40+ | 30 | 3.77 | 2.37 to 5.91 | 4.51 | 2.77 to 7.24 | 1 | 0.27 | 0.01 to 1.27 | 0.33 | 0.02 to 1.60 | 6 | 3.70 | 1.26 to 9.95 | 5.01 | 1.64 to 14.20 | ||||||
NOTE. Adjusted RR is from multivariate Poisson regression model adjusting for all other variables in the table. Twenty-one survivors whose radiotherapy or chemotherapy information was unknown were excluded from analysis.
Abbreviations: LRT, likelihood ratio test; Rb, retinoblastoma; Ref, reference; RR, relative risk.
*
Includes International Classification of Diseases for Oncology morphology codes M8800-8804, 8810-8814, 8830-8833, 8850-8855, 8890-8891, 8894-8895, 8900-8902, 8920, 8990, 9040, 9120, and 9560.