Table 1.

Baseline Demographics and Clinical Characteristics of Carriers and Noncarriers of a Mismatch Repair Gene Mutation

Demographic or Clinical Characteristic	CRC Risk Subcohort				EC Risk Subcohort				Other Cancer Risk Subcohort
	Carriers(n = 365)		Noncarriers(n = 903)		Carriers(n = 215)		Noncarriers(n = 523)		Carriers(n = 446)		Noncarriers(n = 1,029)
	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
MMR gene mutated
MLH1	134	37			87	41			161	36
MSH2	178	49			105	49			222	50
MSH6	40	11			18	8			47	11
PMS2	13	3			5	2			16	3
Sex
Female	201	55	523	58	215	100	523	100	241	54	587	57
Male	164	45	380	42	—		—		205	46	442	43
Race
White	346	96.4	847	96.3	205	97.2	488	96	423	96.4	965	96
Latino/Hispanic	1	0.3	13	1.5	1	0.5	7	1	4	0.9	17	2
Asian	9	2.5	8	0.9	3	1.4	5	1	9	2.0	9	1
Middle Eastern	2	0.6	5	0.6	2	0.9	4	1	2	0.5	6	1
Other	1	0.3	7	0.8	0	0	5	1	1	0.2	7	1
Unknown	6		23		4		14		7		25
Country of recruitment
Canada	24	6	27	3	9	4	23	4	24	5	30	3
United States	50	14	110	12	31	14	69	13	75	17	135	13
Australasia	291	80	766	85	175	81	431	82	347	78	864	84
Source of ascertainment
Population based	59	16	135	15	35	16	77	15	71	16	154	15
Clinic based	306	84	768	85	180	84	446	85	375	84	875	85
Age at recruitment, years
Mean	39.9		48.3		39.8		47.3		41.3		48.9
SD	13.8		15.6		13.1		15.9		13.9		15.4
Follow-up
Total person-years	1,809		4,930		1,061		2,848		2,365		5,880
Mean, years	5.0		5.5		4.9		5.5		5.3		5.7
SD, years	2.5		2.5		2.5		2.5		2.4		2.5
Median, years	4.9		5.4		4.8		5.4		5.2		5.6
Range, years	0.3–11.2		0.1–11.9		0.2–11.2		0.2–11.9		0.4–11.2		0.1–11.9

Abbreviations: CRC, colorectal cancer; EC, endometrial cancer; SD, standard deviation.