Table 3.

Multivariate Analyses^* of Patients With DCIS in NSABP B-24

Model Variable†	Time to Any Breast Cancer As First Event
	HR	95% CI	P
Patients with known ER status (n = 732)
Treatment (placebo‡v tamoxifen)	0.643	0.481 to 0.861	.003
Age at entry, years (≤ 49‡ v ≥ 50)	0.609	0.457 to 0.812	< .001
All patients with follow-up (n = 1,799)
Treatment (placebo‡v tamoxifen)	0.687	0.563 to 0.837	< .001
Age at entry, years (≤ 49‡ v ≥ 50)	0.621	0.510 to 0.756	< .001

Abbreviations: DCIS, ductal carcinoma in situ; ER, estrogen receptor; HR, hazard ratio; NSABP, National Surgical Adjuvant Breast and Bowel Project; PgR, progesterone receptor.

^*End point, any subsequent breast cancer.

^†The following variables were not significantly related to time to any breast cancer in the multivariate analysis: clinical tumor size, ER status, PgR status, comedo necrosis status, and margin status.

^‡Baseline value used for comparison.