Table 4.

Adjusted HR in Mediation Model of Survival

Variable	EPC Randomization			Baseline PHQ-9			Change in PHQ-9 Score at 3 Months
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Without change in depression in model	0.66	0.45 to .95	.03	1.04	1.00 to 1.08	.05
Complete case analysis	0.59	0.36 to .97	.04	1.04	0.99 to 1.10	.12	1.01	0.94 to 1.08	.77
Sensitivity analysis models to account for patients who had died by 12 weeks
Last end point carried forward (improvement = 0)	0.60	0.40 to .910	.02	1.05	0.99 to 1.09	.06	0.99	0.94 to 1.05	.82
Assign average change in sample (improvement = 0.5)	0.60	0.40 to .90	.02	1.04	0.99 to 1.09	.07	1.0	0.94 to 1.06	.99
Assign average change in portion of sample that worsened at 12 weeks (improvement = −3.24)	0.66	0.44 to 1.00	.05	1.07	1.02 to 1.11	.002	0.94	0.89 to .99	.02

Abbreviations: EPC, early palliative care; HR, hazard ratio; PHQ-9, Patient Health Questionnaire-9.