Table 4.
Ovarian Cancer Hazard Ratios in Specific Groups Among Prospective Study Participants (n = 3,787)
| Group | No. of Participants | Age of Ascertainment (years) |
Follow-Up (years) |
No. of Participants Diagnosed With Cancer | Age at Diagnosis (years) |
Hazard Ratio | 95% CI | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Range | Mean | Range | Mean | Range | |||||
| BRCA1 | ||||||||||
| Non-CJM | 1,668 | 40.2 | 2.2-88.6 | 6.0 | 0.0-33.3 | 96 | 50.6 | 30.1-89.3 | Ref | |
| 185delAG | 472 | 43.5 | 10.2-90.4 | 5.1 | 0.0-33.1 | 20 | 53.2 | 36.8-74.0 | 0.97 | 0.58 to 1.63 |
| 5382insC | 228 | 43.4 | 12.3-87.6 | 5.6 | 0.0-25.4 | 6 | 53.6 | 44.8-63.3 | 0.61 | 0.27 to 1.38 |
| BRCA2 | ||||||||||
| Non-CJM | 1,132 | 43.1 | 2.0-89.3 | 5.1 | 0.0-28.3 | 24 | 55.8 | 44.0-74.9 | Ref | |
| 6174delT | 287 | 47.5 | 17.7-76.6 | 4.1 | 0.0-16.2 | 5 | 59.8 | 49.4-76.4 | 1.34 | 0.48 to 3.73 |
| Non-Jewish | 3,034 | 41.5 | 2.0-89.3 | 5.6 | 0.0-33.3 | 127 | 51.7 | 30.1-89.3 | Ref | |
| Jewish | 753 | 45.1 | 10.2-90.4 | 5.0 | 0.0-33.1 | 24 | 54.4 | 36.8-76.4 | 0.93 | 0.59 to 1.46 |
| RRSO | ||||||||||
| No | 2,086 | 39.7 | 2.0-90.4 | 4.5 | 0.0-28.3 | 139 | 52.4 | 30.1-89.3 | Ref | |
| Yes | 1,701 | 45.3 | 15.4-83.7 | 6.6 | 0.0-33.3 | 12 | 49.7 | 37.8-61.6 | 0.08 | 0.04 to 0.16 |
Abbreviations: CJM, common Jewish mutation; Ref, reference; RRSO, risk-reducing salpingo-oophorectomy.