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. 2012 Apr 30;197(3):421–437. doi: 10.1083/jcb.201108143

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© 2012 Pignatelli et al.

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Figure 6. — Rac1 is necessary for GFP–Hic-5 induced matrix degradation. (A) TGF-β–treated MCF10A GFP cells or unstimulated mouse GFP–Hic-5–expressing cells plated on fluorescent gelatin in the presence of vehicle or the Rac1 inhibitor NSC23766. Rac1 inhibition blocks invadopodia formation and matrix degradation. Bar, 20 µm. (B) Quantitation of the percentage of cells associated with matrix degradation. ***, P < 0.0005. The break in the x axis indicates separate sets of experiments, each n = 3. Error bars represent the standard error of the mean.