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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Neurobiol Dis. 2011 Jul 2;44(1):142–151. doi: 10.1016/j.nbd.2011.06.016

Fig. 4.

Fig. 4

(A) Treatment with the p38 MAPK inhibitor SB203580 (20 µM) for 24 h reversed the negative effects of MCM10 on the acetylation levels of histone H3. No changes were observed in the acetylation levels of histone H4. A representative blot is shown. (B) Densitometric analysis of acetyl-H4 and acetyl-H3 protein expression in astrocyte-rich cultures exposed for 24 h to control conditions or MCM10 in the presence or absence of SB203580 (20 µM). Data are plotted as ratio of the protein of interest/tubulin obtained in each condition. Statistics: **p<0.01 vs control; ##p<0.01 vs MCM10. (C) Treatment with the GSK3β inhibitor lithium chloride (LiCl; 5 mM) for 24 h reversed the effects of MCM10 on the acetylation levels of histone H3. No changes were observed in the acetylation levels of histone H4. A representative blot is shown. (B) Densitometric analysis of acetyl-H4 and acetyl-H3 protein expression in astrocyte-rich cultures exposed for 24 h to control conditions or MCM10 in the presence or absence of LiCl (5 mM). Data are plotted as ratio of the protein of interest/tubulin obtained in each condition. Statistics: ***p<0.005 vs control; ###p<0.005 vs MCM10.