Table I.

Classes of Ligands Studied that Interact with AChBP

Class of Ligands	Ligandsa	Lymnaea	Aplysia	(Ac/Ls)b	PDB ID	Reference
Alkaloids	Kd (nM)
	Nicotine	100	260	2.6	1UW6	[10, 19, 29]
	Epibatidine	0.3	8.6	28.7	2BYQ	[11, 19, 29]
	Lobeline	130	0.5	0.0038	2BYS	[11]
	Anabaseine	240	9,000	37.5		[29]
	d-Tubocurarine	67	420	6.3		[18, 31]
	Metocurine	120	570	4.8		[31]
	Methyllycaconitine	0.4	2.8	7	2BYR	[11, 19]
Terpenes
	Bipinnatin H
	Bipinnatin K
Conus Peptides
	α-ImI	14,000	2.1	0.00015	2BYP 2C9T	[11, 33]
	α-OmIA	1.7	6.7	3.9		[21]
	α-PnIA (A10L D14K)	19	21	1.1	2BR8	[32]
	α-PnIA (A10L)	200	28	0.1		[32]
	α-MI	2,800	1,000	0.4		[11]
Elapid Toxins
	α-Bungarotoxin	1.8	170	94.4		[11]
	α-Cobratoxin	15	320	21.3	1YI52	[11]
Neonicotinoids
	Imidacloprid		180			[5]
	Thiacloprid		8.4			[5]
	Acetamiprid		19			[5]
	Nitenpyram		186			[5]
	Clothianidin		574			[5]
Nicotinoids
	Desnitroimidacloprid		44			[5]
	Descyanothiacloprid		8.5			[5]
Allosteric Ligands
	Galanthamine	3,000	16,000	5.3	2PH9	[12]
	Cocaine	6,700	4,500	0.7	2PGZ	[12]

^aSignature ligands have ~ 100 fold or greater differences between the two binding proteins and are noted by the embolden font.

^bRatio of affinities: Aplysia californica/Lymnaea stagnalis