Table 4.
Crude hazard ratios for different outcome events among recruited women in blind versus non-blind trial arms, EPHT Trial: data presented for the periods from 2001 to 2004 and from 2001 to 2007
| Outcome/ Time period |
Recruited women | Non-recruited women | ||
|---|---|---|---|---|
| Blind vs non-blind HT, HR (95% CI) |
Placebo vs non-treatment, HR (95% CI) |
Blind vs non-blind trial, HR (95% CI)* |
Blind vs non- blind trial, HR (95% CI) |
|
| Coronary heart disease | ||||
| 2001-2004 | 0.89 (0.66-1.19) |
0.75 (0.55-1.02) |
0.82 (0.66-1.01) |
1.06 (0.89-1.26) |
| 2001-2007 | 0.77 (0.60-1.00) |
0.78 (0.60-1.01) |
0.77 (0.64-0.93) |
1.01 (0.87-1.18) |
| Cancer | ||||
| 2001-2004 | 0.59 (0.29-1.23) |
0.47 (0.21-1.04) |
0.53 (0.31-0.91) |
0.94 (0.66-1.33) |
| 2001-2007 | 0.77 (0.44-1.33) |
1.23 (0.68-2.23) |
0.95 (0.64-1.42) |
0.90 (0.65-1.24) |
| Cerebrovascular disease | ||||
| 2001-2004 | 0.80 (0.48-1.33) |
0.34 (0.18-0.67) |
0.57 (0.38-0.84) |
1.24 (0.92-1.68) |
| 2001-2007 | 0.80 (0.52-1.24) |
0.51 (0.30-0.86) |
0.66 (0.47-0.92) |
1.15 (0.90-1.46) |
| Bone fractures | ||||
| 2001-2004 | 0.69 (0.43-1.10) |
0.94 (0.65-1.37) |
0.83 (0.62-1.11) |
1.10 (0.87-1.38) |
| 2001-2007 | 0.96 (0.69-1.35) |
0.90 (0.67-1.21) |
0.93 (0.74-1.16) |
1.17 (0.97-1.42) |
| Total mortality | ||||
| 2001-2004 | 0.73 (0.18-3.07) |
0.27 (0.03-2.32) |
0.51 (0.16-1.63) |
0.90 (0.52-1.67) |
| 2001-2007 | 1.22 (0.49-3.08) |
0.86 (0.33-2.22) |
1.03 (0.53-1.98) |
1.02 (0.69-1.52) |
| All outcomes combined | ||||
| 2001-2004 | 0.81 (0.65-1.02) |
0.75 (0.59-0.93) |
0.78 (0.66-0.91) |
1.10 (0.97-1.25) |
| 2001-2007 | 0.83 (0.69-1.02) |
0.81 (0.67-0.98) |
0.82 (0.72-0.94) |
1.08 (0.97-1.21) |
*stratified by treatment