Figure 2. Effect of SpmS, AZ and SSAT on mouse skin carcinogenesis. Mice of the indicated genotype were subjected to DMBA/TPA skin chemical carcinogenesis and tumors were scored weekly. All groups included 17 to 22 animals with an approximately equal number of males and females. Mouse lines are abbreviated as follows: CAG-SpmS, SpmS; K6-AZ, AZ; K6-SSAT, SSAT; and bitransgenic combinations thereof. (A) The percentage of mice in each group with at least one tumor through 22 weeks of promotion. Wild type vs. AZ, p < 0.0001; wild type vs. SpmS, AZ vs. AZ/SpmS, SSAT vs. SSAT/SpmS and wild type vs. SSAT were not significant. (B) The total number of tumors per mouse (mean ± S.E.M.) through 22 weeks of promotion. Wild type vs. AZ, p < 0.0001; wild type vs. SSAT p = 0.011; wild type vs. SpmS, AZ vs. AZ/SpmS and SSAT vs. SSAT/SpmS were not significant.