Figure 3. Polyamine content and ODC and AdoMetDC activities in tumors. (A) Polyamine levels (mean ± S.E.M.) were determined in papillomas (n = 10) from mice with SpmS and/or SSAT overexpression one week after the final TPA application. (B) ODC and SAMDC activity (mean ± S.D.) was determined in papillomas (n = 5) from mice of the indicated genotype one week after the final TPA application. Mouse lines are abbreviated as follows: CAG-SpmS, SpmS; K6-SSAT, SSAT; and bitransgenic combination thereof. a p < 0.05 vs. wild type; b p < 0.01 vs. wild type; c p < 0.005 vs. wild type; d p < 0.001 vs. wild type; e p < 0.05 vs. K6-SSAT.