Figure 3. Histone marks around transcription start sites of genes. Mean normalized H3K4me3 enrichment at non-regulated genes with upstream genes in divergent orientation (A) or tandem orientation (B) (n = 1668 and 1491, respectively). Data are plotted in 3 bp bins and smoothed. Genes were divided into quintiles by Spo11 oligo count in their promoter. TSS is at 0 bp. Box plots show distribution of Spo11 oligo counts for each quintile.