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Figure 4. siRNA-mediated DAPK knockdown rendered cells more resistant to cetuximab and erlotinib. Scramble siRNA or siRNA against DAPK were transfected into H226 cells. DAPK knockdown was confirmed by either real-time RT-PCR (A), or immunoblotting with antibody against DAPK (B). (C) Transfected cells were exposed to either erlotinib or cetuximab and increased resistance was observed after DAPK knockdown.
