Table 4. Associations of potential confounders with genotypes in the three studies.
| Potential Confounders with Genotypes or Allele Score | OR (95% CI) on Logistic Regressiona or on Linear Regressionb | ||
| CGPS | CCHS | CIHDS | |
| Sex a | |||
| FTO (rs9939609) | 1.02 (0.99–1.04) | 0.95 (0.90–1.00) | 1.01 (0.95–1.06) |
| MC4R (rs17782313) | 0.99 (0.96–1.01) | 0.95 (0.89–1.01) | 1.06 (1.00–1.13) |
| TMEM18 (rs6548238) | 0.99 (0.96–1.03) | 0.95 (0.89–1.03) | 1.02 (0.94–1.09) |
| Allele score | 1.00 (0.98–1.02) | 0.95 (0.92–0.99) | 1.03 (0.99–1.07) |
| Ever smoked a | |||
| FTO (rs9939609) | 1.02 (1.00–1.05) | 0.95 (0.90–1.01) | 1.03 (0.97–1.09) |
| MC4R (rs17782313) | 1.01 (0.98–1.04) | 1.02 (0.95–1.08) | 0.98 (0.91–1.04) |
| TMEM18 (rs6548238) | 1.03 (1.00–1.06) | 1.05 (0.97–1.12) | 1.00 (0.92–1.08) |
| Allele score | 1.02 (1.00–1.04) | 1.00 (0.96–1.03) | 1.00 (0.96–1.04) |
| Drinking b | |||
| FTO (rs9939609) | 0.97 (0.95–1.00) | 0.93 (0.88–0.99) | 1.00 (0.94–1.06) |
| MC4R (rs17782313) | 0.99 (0.96–1.03) | 0.95 (0.89–1.01) | 0.99 (0.92–1.06) |
| TMEM18 (rs6548238) | 0.98 (0.95–1.02) | 1.03 (0.96–1.11) | 1.01 (0.93–1.10) |
| Allele score | 0.98 (0.97–1.00) | 0.96 (0.93–1.00) | 1.00 (0.96–1.04) |
| Age (y) b | |||
| FTO (rs9939609) | −0.02 (−0.19 to 0.15) | 0.06 (−0.38 to 0.50) | 0.09 (−0.26 to 0.44) |
| MC4R (rs17782313) | 0.10 (−0.10 to 0.30) | 0.15 (−0.36 to 0.65) | 0.25 (−0.14 to 0.63) |
| TMEM18 (rs6548238) | −0.05 (−0.27 to 0.16) | 0.69 (0.11–1.27) | 0.04 (−0.41 to 0.50) |
| Allele score | 0.02 (−0.10 to 0.13) | 0.24 (−0.05 to 0.53) | 0.13 (−0.09 to 0.36) |
| Event time b | |||
| FTO (rs9939609) | 0.00 (−0.03 to 0.03) | 0.01 (−0.14 to 0.15) | 0.02 (−0.04 to 0.08) |
| MC4R (rs17782313) | −0.01 (−0.04 to 0.02) | 0.05 (−0.12 to 0.21) | −0.03 (−0.09 to 0.04) |
| TMEM18 (rs6548238) | 0.02 (−0.02 to 0.05) | −0.16 (−0.35 to 0.03) | 0.05 (−0.03 to 0.12) |
| Allele score | 0.00 (−0.02 to 0.02) | −0.02 (−0.12 to 0.08) | 0.01 (−0.03 to 0.05) |
| Education a | |||
| FTO (rs9939609) | 0.99 (0.96–1.02) | 0.92 (0.85–1.01) | 0.95 (0.86–1.04) |
| MC4R (rs17782313) | 1.00 (0.97–1.04) | 0.93 (0.84–1.03) | 0.94 (0.84–1.05) |
| TMEM18 (rs6548238) | 1.00 (0.96–1.04) | 0.95 (0.85–1.06) | 0.91 (0.80–1.04) |
| Allele score | 0.99 (0.97–1.02) | 0.93 (0.88–0.99) | 0.94 (0.88–1.00) |
| Income a | |||
| FTO (rs9939609) | 0.99 (0.96–1.03) | 0.98 (0.85–1.13) | 0.99 (0.93–1.06) |
| MC4R (rs17782313) | 0.98 (0.95–1.02) | 0.96 (0.81–1.13) | 1.03 (0.95–1.11) |
| TMEM18 (rs6548238) | 0.94 (0.91–0.98) | 0.90 (0.75–1.08) | 1.00 (0.91–1.10) |
| Allele score | 0.98 (0.96–1.00) | 0.96 (0.87–1.05) | 1.01 (0.96–1.05) |
Drinking represented by <14/21; ≥14/21 units per week for women/men at the time of examination. Education represented by less or more than 13 y schooling. Income represented by annual income less or more than 400,000DKK. Event time is absolute difference between age at IHD event and age at measurement of BMI (y).
a
Logistic regression.
b
Linear regression.