Table 2. Overlapping signaling pathways between human PD transcriptome studies and signaling pathways in VMB of PQ, PY and MNPQ mouse models of PD.

IPA Pathway Category	Ventral mid brain (VMB) pathways common with human
	SN [17]	BA9 [17]	PU [17]	SFG [14]	L SN [14]	M SN [14]	SN [37]	OC[15]	PU [15]
Amyotrophic Lateral Sclerosis Signaling				x				x
Glutamate Receptor Signaling				x	x
Calcium Signaling		x						x	x
Actin Cytoskeleton Signaling				x		x	x
PTEN Signaling		x		x	x	x
LXR/RXR Activation	x
PPAR Signaling	x	x				x	x
PPARα/RXRα Activation	x
ERK/MAPK Signaling		x		x				x
Axonal Guidance Signaling		x			x		x	x
IL-6 Signaling	x	x
Ephrin Receptor Signaling	x	x		x		x
Erythropoietin Signaling								x
G-Protein Coupled Receptor Signaling			x		x	x		x
RAR Activation		x					x	x
IGF-1 Signaling	x	x		x		x	x	x
JAK/Stat Signaling	x	x		x		x	x
Death Receptor Signaling		x
Aryl Hydrocarbon Receptor Signaling							x	x
PI3K/AKT Signaling	x	x		x			x
Hepatic Cholestasis	x
IL-10 Signaling	x

All human IPA analysis were performed by [18].

x = Common Pathways.

SN: Substantia nigra, BA9: Brodman area 9, SFG: Superior frontal gyrus, L SN: Lateral substantia nigra, M SN: Medial substantia nigra, PU: Putamen, OC: Occipital cortex.