Table 3. Overlapping signaling pathways between human PD transcriptome studies and signaling pathways in STR of PQ, PY and MNPQ mouse models of PD.

IPA Pathway category	Striatum (STR) pathways common with human
	SN [17]	BA9 [17]	PU [17]	SFG [14]	L SN [14]	M SN [14]	SN [37]	OC [15]	PU [15]
Calcium Signaling		x						x	x
PTEN Signaling		x		x	x	x	x
Amyotrophic Lateral Sclerosis Signaling				x				x
Axonal Guidance Signaling		x			x		x	x
IL-6 Signaling	x	x
G-Protein Coupled Receptor Signaling			x		x	x		x
Hepatic Cholestasis	x
PPARα/RXRα Activation	x
Cardiac β-adrenergic Signaling		x			x
Estrogen Receptor Signaling						x	x	x
Wnt/β-catenin Signaling		x
Serotonin Receptor Signaling									x
LXR/RXR Activation	x

All human IPA analysis were performed by [18].

x = Common Pathways.

SN: Substantia nigra, BA9: Brodman area 9, SFG: Superior frontal gyrus, L SN: Lateral substantia nigra, M SN: Medial substantia nigra, PU: Putamen, OC: Occipital cortex.