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. 2012 May 1;7(5):e36302. doi: 10.1371/journal.pone.0036302

Figure 6. The effect of CK-165 and sildenafil in rats with monocrotaline-induced pulmonary hypertension.

Figure 6

CK-165 decreased RSVP following intratracheal nebulization of 30 mg/kg in rats with monocrotaline induced pulmonary artery hypertension by 18.0±3.8% (p<0.05) when compared with vehicle treated group. The decrease is similar to that in monocrotaline rats treated with 100 mg/kg/day sildenafil (20.3±4.5%) for 7 days and treatment with CK-165 does not appear to have additive effects when co-administered with sildenafil.