Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 May 1;7(5):e36302. doi: 10.1371/journal.pone.0036302

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Ho et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

CK-2018571 inhibits phenylephrine-induced pulmonary artery contraction in isolated tissue rings from naïve and monocrotaline-treated rats. Pulmonary artery rings were pre-contracted with 1 µM phenylephrine and isometric tension was recorded in the presence of increasing concentrations of CK-2018571. CK-2018571 elicited relaxation in tissues from naïve rats with pEC₅₀ = 6.08±0.03, and in tissues from monocrotaline-treated rats with pEC₅₀ = 6.08±0.10.