Table 2. Effects of Thromboxane and Subsequent CK-2019165 or Nitroprusside in Anesthetized Pigs.

	Pre-Hypertension Baseline	Pulmonary Hypertension baseline	Thromboxane Peak (CK-165) % Change	Thromboxane Peak (Nitroprusside) % Change
	(n = 5)	(n = 5)	(n = 4)	(n = 5)
Heart Rate (bpm)	128±4.3	130±6.9	6.7±2.7%	5.1±1.7%†
Mean Arterial Pressure (mmHg)	100±5.1	112±6.2	−24.5±2.5%‡ #	−13.6±3.6%‡
Mean Pulmonary Artery Pressure (mmHg)	18.5±0.9	34.7±1.4**	−17.4±5.4%†	−15.6±3.0%‡
Pulmonary Blood Flow (L/min)	3.2±0.4 (n = 4)	3.0±0.4 (n = 4)	14.85±3.4%† ##	1.42±1.8%
Pulmonary vascular resistance (mmHg/L/min)	4.5±0.9 (n = 4)	10.0±1.8* (n = 4)	−28.2±5.5%†	−14.3±4.2%†

^*p<0.05 Pulmonary Hypertension vs. Pre-Hypertension Baseline.

^**p<0.01 Pulmonary Hypertension vs. Pre-Hypertension Baseline.

^†p<0.05 Hypertension Baseline vs. Subsequent CK-2019165 or nitroprusside.

^‡p<0.01 Hypertension Baseline vs. Subsequent CK-2019165 or nitroprusside.

^#p<0.05 CK-2019165 vs. nitroprusside.

^##p<0.01 CK-2019165 vs. nitroprusside.