Figure 3. Effect of various MDR inhibitors on calcein accumulation in olfactory slices of rat and mouse.

Olfactory tissue slices were incubated with 1 µM calcein-AM in the absence or presence of the specific MDR inhibitors. Bars represent average accumulation rates as determined from slopes over all time points of the experiment, in (A) from mice, and in (B) from rats. The following inhibitors were tested: vera  =  verapamil at 100 and 200 µM, CsA  =  cyclosporin A at 5 and 10 µM, prob  =  probenecid at 2.5 and 5 mM, and MK  =  MK571 at 25 and 50 µM. Values from at least three independent assays for each inhibitor and concentration. * p<0.05.