Table 3. Association to the chromosome 5p13 region in Danish multiplex/simplex families, BDD cohort and the Swedish case-control material.

Marker name	Danish families			Swedish-Danish families	Swedish case-control				BDD cohort		MS controls		Pooling of data
					Patients	Controls			Patients		Controls
					n = 778	n = 836			n = 2700		n = 527
	Minor allele frequency	Call rate %	p-value	p-value	Genotypefrequency% AA/AB/BB	Genotypefrequency% AA/AB/BB	Call rate%	p-value	Genotypefrequency% AA/AB/BB	Call rate%	Genotypefrequency% AA/AB/BB	p-value	p-value
rs1364043					59.5/35.3/5.1	61.4/33.6/4.9	93	0.5
rs878567	0.50	95	0.05	0.015	25.6/49.9/24.5	24.4/51.8/23.8	89	0.9
rs6449693	0.50	93	0.06	0.04	25.6/50.2/24.1	25.9/49.6/24.4	81	0.9
rs6295	0.50	92	0.04	0.003	27.5/50.9/21.6	26.6/49.6/23.8	89	0.4	27.2/50.0/22.9	95	26.6/50.1/23.4	0.4	0.01
rs1364041					77.7/20.6/1.7	78.2/19.7/2.0	83	0.8
rs356562					37.5/49.3/13.3	37.3/47.2/15.5	94	0.5
rs356570	0.38	95	0.001	8.5×10−5	38.8/48.6/12.6	39.5/46.5/14.0	94	0.8	40.8/45.3/13.9	97	41.5/44.4/14.1	0.6	0.003
rs12697015					73.1/25.3/1.6	71.9/26.0/2.2	93	0.5
rs6880454	0.07	91	0.5	0.02	82.8/15.5/1.7	83.5/15.1/1.4	70	0.2	82.3/16.8/1.1	95	83.1/16.1/0.8	0.5	0.05

Allele frequencies and p-values for the Danish multiplex-simplex families and p-values for the Swedish cases-control and BDD studies were obtained from Unphased v. 3.0.6. P-values for the BDD cohort were obtained using controls from the Swedish MS case-control study.

Genotype frequencies and p-values for the genotype test were obtained by using chi2 test.