Figure 8. VILI-induced cytokine production was not altered by IMD.
Mice were ventilated with a tidal volume of 12 ml/kg for 6 h and treated with IMD 0.025 mg/kg*h (6h vent.+IMD) or solvent (6h vent). NV = non-ventilated mice. A) IL-1β, IL-18, IL-6, KC, MIP-1α, MIP-2, MCP-1, IL12p40 were detemined in lung homogenate by multiplex assay technique. (*p<0.05 vs. NV, **p<0.01 vs. NV n = 8) B) IL-1β, IL-18, IL-6, KC, MIP-1α, MIP-2, MCP-1, IL12p40 were determined in plasma by multiplex assay technique. (*p<0.05 vs. NV, **p<0.01 vs. NV n = 8).