Figure 1. Regulatory Snapshots method.

This figure shows an overview of the proposed method, Regulatory Snapshots, to mine regulatory modules from expression time series and regulatory associations in two steps. First, biclustering is applied to expression time series to find transcriptionally coherent genes and group them in transcriptional modules (biclusters). A personalized ranking strategy is then used to compute relevance scores for the transcription factors targeting the genes in the biclusters at each time point. Finally, regulators are sorted by relevance and a graphical representation, termed regulatory snapshot, is depicted to expose the architecture of the regulatory module.