Figure 7. The effect of two Spiroindolines and vesamicol on the survival of parental and mutant C. elegans larvae to adulthood.

Black lines represent sensitivity of the wild-type strain N2. Coloured lines represent sensitivity of the mutant alleles selected for resistance to SYN351; cb28 (magenta), cb29 (red), cb30 (green), cb34 (cyan). Solid symbols represent the means, and bars represent the maximum and minimum values for three replicate experiments. The amino acid change for each mutant allele is indicated in Figure 8.