Figure 9. Binding of Spiroindolines in insect tissues.

A - Saturation isotherm for the binding of [³H]-SYN876 in the blowfly L. sericata. Data from two independent experiments is combined and analyzed by fitting to a single site binding model (y = Bmax * x/(Kd+x)). The line represents the theoretical curve for the indicated values of Kd and Bmax. B - Two way correlation plots comparing the pharmacology of [³H]-SYN876 displacement between insect orders. S. littoralis,(Lepidoptera); L. Sericata, (Diptera); and Locusta migratoria, (Orthoptera). Data for the 24 analogues used is given in table S3.