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. 2012 Mar 31;39(1):10–14. doi: 10.5653/cerm.2012.39.1.10

Figure 1.

Figure 1

Illustration of the PI3K pathway signaling pathway. Molecules that maintain the dormancy of the primordial follicles are PTEN, Foxo3a, p27, and TSC1/TSC2. Molecules that maintain the survival of primordial follicles include PI3K, PDK1, mTORC1, S6K1, and rpS6. RPTK, receptor protein tyrosine kinase; PTEN, phosphatase and tensin homolog; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-triphosphate; PI3K, phosphatidylinositol 3-kinase; PDK1, 3-phosphoinositide-dependent protein kinase-1; Akt, protein kinase B; FOXO3a, forkhead box O3a; mTORC1,C2, mammalian target of rapamycin complex 1,2; TSC1/2, tuberin/tuberous sclerosis complex 1,2; S6K1, p70 ribosomal protein S6 kinase 1; rpS6, S6K1-ribosomal protein S6; p27, cyclin-dependent kinase inhibitor p27Kip1 (Modified from Reddy et al. [22]).