Table 2.

Intention-to-treat vaccine efficacy against Plasmodium falciparum clinical malaria episodes

	RTS,S/AS01E				Rabies vaccine				Vaccine efficacy
	Number of individuals	Number of episodes	PYAR	Event rate	Number of individuals	Number of episodes	PYAR	Event rate	% (95% CI)	p value
First or only episode, 14 months
≥2500 parasites per μL	447	92	482	0·19	447	139	459	0·30	39 (20–53)	<0·001
>0 parasites per μL	447	101	477	0·21	447	147	454	0·32	36 (18–50)	<0·001
All multiple episodes, 14 months
≥2500 parasites per μL	447	140	515	0·27	447	239	515	0·46	44 (24–58)	<0·001
>0 parasites per μL	447	162	514	0·32	447	272	514	0·53	43 (24–57)	<0·001
First or only episode, 18 months
≥2500 parasites per μL	223	64	269	0·24	224	92	245	0·38	37 (14–55)	0·004
>0 parasites per μL	223	72	264	0·27	224	98	240	0·41	34 (11–51)	0·007
All multiple episodes, 18 months
≥2500 parasites per μL	223	119	305	0·39	224	197	301	0·65	44 (20–61)	0·002
>0 parasites per μL	223	137	305	0·45	224	226	300	0·75	43 (20–60)	0·001

Analyses at 14 months for Kilifi and Korogwe. Analyses at 18 months for Kilifi only. PYAR=event rates per person year at risk.