Table 5.

Amount of progression on the MMSE and CDR-SB at 1, 3, and 5 years after baseline by sex, APOE ε4 status, and Persistency Index (PI)

	After 1 Year	After 3 Years	After 5 Years
	b (95% CI)	b (95% CI)	b (95% CI)
MMSE
Male
no ε4 allele
PI=0	−0.50 (−1.30, 0.30)	−2.20 (−4.28, −0.11)	−4.82 (−8.05, −1.58)
PI=1	−1.12 (−4.90, 2.66)	−3.59 (−10.89, 3.71)	−6.36 (−19.28, 6.55)
1 or 2 ε4 alleles
PI=0	−0.96 (−1.88, −0.04)	−3.38 (−5.82, −0.95)	−6.50 (−10.41, −2.59)
PI=1	−1.36 (−3.71, 0.99)	−7.91 (−13.23, −2.59)	−19.55 (−28.87, −10.22)
Female
no ε4 allele
PI=0	−2.43 (−3.02, −1.84)	−6.99 (−8.49, −5.50)	−11.16 (−13.49, −8.83)
PI=1	−0.95 (−5.30, 3.40)	−7.69 (−15.66, 0.27)	−20.89 (−39.12, −2.65)
1 or 2 ε4 alleles
PI=0	−1.44 (−2.12, −0.76)	−5.38 (−7.18, −3.58)	−10.72 (−13.66, −7.79)
PI=1	−1.03 (−2.55, 0.49)	−2.32 (−6.17, 1.52)	−2.58 (−9.11, 3.96)
CDR-Sum
Male
no ε4 allele
PI=0	0.40 (−0.29, 1.09)	1.66 (−0.15, 3.47)	3.54 (0.74, 6.33)
PI=1	1.19 (−2.13, 4.51)	0.90 (−5.42, 7.22)	−2.93 (−14.12, 8.27)
1 or 2 ε4 alleles
PI=0	1.10 (0.37, 1.84)	3.38 (1.53, 5.23)	5.74 (2.91, 8.57)
PI=1	0.27 (−1.74, 2.28)	6.04 (1.90, 10.18)	18.79 (11.83, 25.75)
Female
no ε4 allele
PI=0	1.68 (1.18, 2.18)	5.05 (3.79, 6.31)	8.46 (6.50, 10.41)
PI=1	−0.76 (−3.83, 2.31)	0.76 (−5.82, 7.34)	6.34 (−5.26, 17.93)
1 or 2 ε4 alleles
PI=0	0.77 (0.23, 1.32)	3.44 (2.08, 4.80)	7.60 (5.47, 9.74)
PI=1	1.31 (0.10, 2.52)	3.21 (0.25, 6.17)	4.14 (−0.66, 8.95)

Abbreviations: MMSE=Mini-mental state examination; CDR-Sum = Clinical Dementia Rating scale - Sum of boxscores; PI=Persistency Index