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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Free Radic Biol Med. 2012 Mar 6;52(9):1820–1827. doi: 10.1016/j.freeradbiomed.2012.02.043

Figure 4.

Figure 4

Effect of Gpx4 ablation on mitochondrial function.

A. The levels of 4-HNE protein adducts in liver whole homogenates and mitochondrial fractions of tam-treated Gpx4(f/f)/Cre mice and tam-treated Gpx4(f/f) mice. The activities of electron transport chain complex I (B), II (C), III (D), IV (E), and ATP generation (F) of isolated mitochondria from liver were measured in tam-treated Gpx4(f/f)/Cre mice and tam-treated Gpx4(f/f) mice. The data representing mean ± SEM are shown. (*: p <0.05, n=3). G/M: glutamate plus malate; Suc/Rot: succinate plus rotenone.