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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Free Radic Biol Med. 2012 Mar 9;52(9):1760–1766. doi: 10.1016/j.freeradbiomed.2012.02.052

Fig. 6. A schematic representation of the involvement of Nox1 in the modulation by TPr of IL-1β-induced monocyte adhesion.

Fig. 6

In VSMCs, IL-1β activates NF-κB leading to Nox1, VCAM-1 and iNOS expression. The TPr agonist U46619 augments both Nox1 and VCAM-1 expression through activation of JNK/AP-1 signaling, but inhibits iNOS expression induced by IL-1β. Adhesion of monocytes to VSMC is regulated by the balance of VCAM-1 expression, and nitric oxide (NO) and superoxide anion (O2.−) production. Activation of TPr results in increased expression of Nox1 that enhances superoxide generation, which inactivates nitric oxide produced by iNOS, likely forming peroxynitrite (OONO−), and contributes to enhanced monocyte adhesion.