Table 2.
Changes in lipids among 151 HIV-infected children before starting treatment (pre-treatment) with ritonavir-boosted lopinavir (LPV/r)-based therapy and at the time of randomization after achieving virologic suppression (suppressed) on this regimen.
| Pre-treatment (Time 0) | Suppressed (Time 0R) | ||||
|---|---|---|---|---|---|
| Mean [standard deviation] | Mean [standard deviation] | ||||
| Continuous variable | mmol/l | mg/dL | mmol/l | mg/dL | p-value* |
| Total Cholesterol (TC) | 2.62 [0.78] | 102 [30.3] | 3.71 [0.97] | 145 [38.0] | <0.0001 |
| Low density lipoprotein (LDL) | 1.11 [0.71] | 43 [27.7] | 1.98 [0.85] | 77 [33.3] | <0.0001 |
| High Density lipoprotein (HDL) | 0.59 [0.33] | 23 [13.0] | 1.03 [0.34] | 40 [13.3] | <0.0001 |
| Triglycerides (TG) | 2.02 [0.86] | 180 [76.2] | 1.64 [0.87] | 146 [77.6] | <0.0001 |
| TC:HDL ratio | 6.35 [5.08] | 3.90 [1.37] | |||
| Categorical classification | n/N† (%) | n/N (%) | |
|---|---|---|---|
|
| |||
| Total cholesterol | |||
| Borderline high 170-199 mg/dL | 3/144 (2.1) | 26/144 (18.1) | |
| High ≥ 200 mg/dL | 0 | 8/144 (5.6) | <0.0001 |
|
| |||
| Low density lipoprotein (LDL) | |||
| Borderline high 110-129 mg/dL | 2/144 (1.4) | 7/143 (4.9) | |
| High ≥ 130 mg/dL | 0 | 10/143 (7.0) | 0.003 |
|
| |||
| High density lipoprotein (HDL) | |||
| Low < 40 mg/dL | 134/144 (93.1) | 87/146 (59.6) | <0.0001 |
|
| |||
| Triglycerides | |||
| High >150 mg/dl | 93/147 (63.3) | 55/146 (37.7) | <0.0001 |
*
Paired t-tests were used for continuous variables and McNemar tests for categorical variables