Table 3.
Summary of PTEN exon sequence abnormalities (insertions, deletions, and point mutations) and endometrial carcinoma type.
| ENDOMETRIOID | NON-ENDOMETRIOID | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| All Sequence Abnormalities Detected n(%)1 | Insertions and deletions | Point Mutations | All Sequence Abnormalities Detected n(%)1 | Insertions and deletions | Point Mutations | |
| Exon 1 | 9 (12.9%) | 5 | 4 | 5 (26.3%) | 2 | 3 |
| Exon 2 | 2 (2.9%) | 0 | 2 | 0 (0%) | 0 | 0 |
| Exon 3 | 2 (2.9%) | 0 | 2 | 0 (0%) | 0 | 0 |
| Exon 4 | 1 (1.4%) | 0 | 1 | 1 (5.3%) | 1 | 0 |
| Exon 5 | 12 (17.1%) | 4 | 8 | 4 (21.1%) | 1 | 3 |
| Exon 6 | 10 (14.3%) | 5 | 5 | 0 (0%) | 0 | 0 |
| 1 Exon 7 | 14 (20.0%) | 10 | 4 | 1 (5.3%) | 1 | 0 |
| Exon 8 | 16 (22.9%) | 7 | 9 | 5 (26.3%) | 3 | 2 |
| Exon 9 | 0 (0%) | 0 | 0 | 1 (5.3%) | 1 | 0 |
| Exon 3 boundary | 1 (1.4%) | 1 | 0 | 0 (0%) | 0 | 0 |
| Exon 8 boundary | 0 (0%) | 0 | 0 | 1 (5.3%) | 1 | 0 |
| Splice region 6/7 | 2 (2.9%) | 0 | 2 | 1 (5.3%) | 0 | 1 |
| Splice region 7/8 | 1 (1.4%) | 0 | 1 | 0 (0%) | 0 | 0 |
|
| ||||||
| All | 70 | 32 | 38 | 19 | 10 | 9 |
1
Exon 7 sequence abnormalities were significantly more common in endometrioid carcinomas compared to the non-endometrioid group (p=0.0199).