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Effects on hourglass-shaped ion channels
| Phase | ΔP1 (kBT/Å) | ΔP2 (kBT) | α | K/K0 | ||
|---|---|---|---|---|---|---|
| POPC/SM/Cer | Lα | 0.062 | 16.8 | −7.7 | 4.5 × 10−4 | ↑ |
| Lβ | −0.31 | −16.9 | 18.3 | 9.3 × 107 | ↓ | |
| POPC/SM/Cer/Chol | Lα | 0.005 | 0.64 | −0.4 | 6.5 × 10−1 | ↑ |
| Lβ | −1.16 | −8.4 | 55.1 | 8.7 × 1023 | ↓ |
Changes of first and second integral moments, P1 and P2, of the lateral-pressure profiles and the consequences for conformational equilibria K/K0. Up and down arrows indicate shifts toward channel opening and channel closing, respectively.
