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Dependence on extracellular pH of the transient currents of the mutants E211D and E211D/E268A. (A–C) Voltage-clamp recordings from one oocyte expressing E211D/E268A at the indicated conditions of pH and [Cl−]ext. (D) Q(V)-relationships of this oocyte are superimposed with fits of Eq. 1. Average values are shown for V1/2 (E) and the apparent gating valence, z (F), as a function of pHext. Error bars indicate mean ± SE (n ≥ 3).
