Figure 5.

Effects of PMCA adaptation to maintain constant diastolic [Ca²⁺]_i on ATP consumption as a function of V_up. (A) ATP consumption per cardiac cycle by SERCA, PMCA, and NKA, and total consumption in the four-week KO model. (B) ATP consumption per cardiac cycle by SERCA, PMCA, and NKA and total consumption in the seven-week KO model. (C) The rates of change in ATP consumption by different processes plotted in panel A. See text for details. (D) The rates of change in ATP consumption by different processes plotted in panel B.