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. 2012 Apr 24;2(2):e000773. doi: 10.1136/bmjopen-2011-000773

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© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

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Statistical parametric mapping of the brain regions correlated with baseline profiles in Studies on Diagnosis of Early Alzheimer's Disease—Japan (SEAD-J) and Alzheimer's Disease Neuroimaging Initiative (ADNI). The regions displayed in red indicate significant regional hypometabolism (p<0.05). (A) Inverse correlation between Geriatric Depression Scale (GDS) scores and glucose metabolism. (B) Inverse correlation between age and glucose metabolism.